89730  Trichostatin A

TSA (CAS 58880-19-6)



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• See more Histone Deacetylase; Nuclear Receptors; Cancer; Epigenetics

For active pharmaceutical ingredients (APIs) related to Trichostatin A, see Cayman Pharma

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of the HDAC1 with an IC50 value of 70 nM.1 Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.2
1  Hoshikawa, Y., Kwon, H.J., Yoshida, M., et al. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Exp Cell Res 214 189-197 (1994).
2  Taunton, J., Hassig, C.A., Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272 408-411 (1996).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
500 µg €57.00
1 mg €107.00
5 mg €452.00
10 mg €790.00
Pricing updated 2010-09-07.
Prices are subject to change without notice.