70660  Methyl Arachidonyl Fluorophosphonate

MAFP



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• See more Fatty Acid Amides; Phospholipase; Neuroscience

For active pharmaceutical ingredients (APIs) related to Methyl Arachidonyl Fluorophosphonate, see Cayman Pharma

Methyl arachidonyl fluorophosphonate (MAFP) is a selective, active-site directed, irreversible inhibitor of cPLA2 and iPLA2.1,2,3 It inhibits A23187-induced arachidonic acid release from human platelets with an IC50 value of 0.6 µM.1 The IC50 value for inhibition of iPLA2 from P388D1 cells is 0.5 µM.2 MAFP is a potent inhibitor of fatty acid amide hydrolase, exhibiting an IC50 value of 2.5 nM. MAFP also binds to the CB1 receptor in rat brain membrane preparations. The IC50 values for MAFP and arachidonyl ethanolamide in this assay are 20 and 40 nM, respectively.4
1  Huang, Z., Liu, S., Street, I., et al. Methyl arachidonyl fluorophosphonate, a potent irreversible cPLA2 inhibitor, blocks the mobilization of arachidonic acid in human platelets and neutrophils. Mediators Inflamm 3 307-308 (1994).
2  Lio, Y., Reynolds, L.J., Balsinde, J., et al. Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta 1302 55-60 (1996).
3  Balsinde, J., Dennis, E.A. Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages. J Biol Chem 271 6758-6765 (1996).
4  Deutsch, D.G., Omeir, R., Arreaza, G., et al. Methyl arachidonyl fluorophosphonate: A potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol 53 255-260 (1997).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Size Price Quantity
1 mg €24.00
5 mg €108.00
10 mg €192.00
50 mg €840.00
Pricing updated 2010-09-07.
Prices are subject to change without notice.