62750  Thioetheramide-PC

1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine (CAS 116457-99-9)



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Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2).1,2 The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.1 In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.1
1  Yu, L., Deems, R.A., Hajdu, J., et al. The interaction of phospholipase A2 with phospholipid analogues and inhibitors. J Biol Chem 265 2657-2664 (1990).
2  Plesniak, L.A., Boegeman, S.C., Segelke, B.W., et al. Interaction of phospholipase A2 with thioether amide containing phospholipid analogues. Biochemistry 32 5009-5016 (1993).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Warning This product is not for human or veterinary use.

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Size Price Quantity
1 mg €26.00
5 mg €114.00
10 mg €202.00
25 mg €442.00
Pricing updated 2010-09-09.
Prices are subject to change without notice.