500151  Prostaglandin D2-MOX Express EIA Kit

PGD2-MOX EIA Express Kit; Prostaglandin D2-MOX Express ELISA Kit



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• See more EIA (Enzyme Immunoassay); Assay Kits; Prostaglandins

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Let Cayman analyze your samples for you. See EIA Service for details and availability.

For active pharmaceutical ingredients (APIs) related to Prostaglandin D2-MOX Express EIA Kit, see Cayman Pharma

Limit of detection: 80% B/B0: 16 pg/ml · Sensitivity: 50% B/B0: 75.2 pg/ml · Prostaglandin D2 (PGD2) is biosynthesized in the brain by a lipocalin-type PGD2 synthase where it acts in the CNS to promote sleep induction and lowering of body temperature.1 PGD2 is also the major eicosanoid product of mast cells and is synthesized in large quantities by a hematopoetic-type PGD synthase during allergic and asthmatic anaphylaxis.2,3 Measurement of the parent eicosanoid PGD2 is appropriate in the supernatants of cell cultures, where PGD2 levels may reach several ng/ml, and in CSF, where concentrations of several hundred pg/ml have been measured.4 Cayman Chemical’s PGD2-MOX Express EIA is a competitive assay that permits the rapid measurement of PGD2 from biological samples, requiring only 1 hour incubation and development times for each step. The methodology for the assay is the same as that employed in Cayman’s widely utilized PGD2-MOX EIA (Catalog No. 512011). While Catalog No. 512011 offers superior sensitivity (IC50 ~20 pg/ml), the new PGD2-MOX Express EIA offers the convenience of a fast assay while still achieving an IC50 of 75 pg/ml and a detection limit (80% B/B0) of approximately 16 pg/ml.
1  Hayaishi, O. Sleep-wake regulation by prostaglandins D2 and E2. J Biol Chem 263 14593-14596 (1988).
2  Mahmud, I., Ueda, N., Yamaguchi, H., et al. Prostaglandin D synthase in human megakaryoblastic cells. J Biol Chem 272 28263-28266 (1997).
3  Matsuoka, T., Hirata, M., Tanaka, H., et al. Prostaglandin D2 as a mediator of allergic asthma. Science 287 2013-2017 (2000).
4  Ram, A., Pandey, H.P., Matsumura, H., et al. CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats. Brain Res 751 81-89 (1997).

Download Kit Booklet 915 Kb PDF
Download Abbreviated Kit Protocol 435 Kb PDF
Download Material Safety Data Sheet (MSDS) 210 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

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Size Price Quantity
96 wells €320.00
480 wells €1,198.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.

Many of our kits require a source of UltraPure Water. If you do not have a source it is available for purchase from Cayman Chemical. Please check the Additional Items Required section of this kit booklet to verify if Ultra Pure Water is needed. Please note that the 480 well kits are supplied with a single 500 dtn vial of tracer and antiserum that must be used within the stated time following reconstitution. Please see the individual kit booklets for these details or contact techserv@caymanchem.com.