360900  PAF C-16-d4

Platelet-activating Factor C-16-d4 (CAS 211106-54-6)


PAF C-16-d4 contains four deuterium atoms at the 7, 7', 8, and 8' positions of the hexadecyl moiety. It is intended for use as an internal standard for the quantification of PAF C-16 by GC- or LC-mass spectrometry. PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways.1 It is a potent mediator of neutrophil migration,2 the production of reactive oxygen species,3 and IL-64 in human macrophages. It is a more potent mediator of platelet aggregation than PAF C-185. Pathological processes involving PAF include necrotizing enterocolitis,6 inflammation, asthma, and allergy.7
1  S. M. Prescott, G. A. Zimmerman and T. M. McIntyre. Platelet-activating factor. The Journal of Biological Chemisty 265 17381-17384 (1990).
2  E. J. Carolan and T. B. Casale. Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular species. Journal of Immunology 145 2561-2565 (1990).
3  M. Rouis, F. Nigon and M. J. Chapman. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochemical and Biophysical Research Communications 156 1293-1301 (1988).
4  M. Thivierge and M. Rola-Pleszczynski. Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. Journal of Allergy and Clinical Immunology 90 796-802 (1992).
5  A. G. Stewart and G. Grigoriadis. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. Journal of Lipid Mediators 4 299-308 (1991).
6  H. Wang, X. D. Tan, X. W. Qu, et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximide. Pediatric Research 42 597-603 (1997).
7  A. Sturk, J. Wouter Ten Cate, D. Hosford, et al. The synthesis, catabolism, and pathophysiological role of platelet-activating factor. Advances in Lipid Research 23 219-276 (1989).

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100 µg €23.00
500 µg €104.00
1 mg €183.00
Pricing updated 2016-09-26.
Prices are subject to change without notice.