319500  11-dehydro Thromboxane B2-d4

11-keto TXB2-d4



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• See more Mass Spectrometry; Thromboxanes; Atherosclerosis

For active pharmaceutical ingredients (APIs) related to 11-dehydro Thromboxane B2-d4, see Cayman Pharma

11-dehydro TXB2-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 11-dehydro TXB2 by GC- or LC-mass spectrometry. TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.1 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivo TXA2 synthesis.1,2,3,4 The mean plasma level in human males is 0.9-4.3 pg/ml and the half life is 45-60 minutes.2,3,4
1  Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim Biophys Acta 992 66-70 (1989).
2  Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv Prostaglandin Thromboxane Leukot Res 15 87-90 (1985).
3  Takasaki, W., Nakagawa, A., Tanaka, Y., et al. Enzyme immunoassay of human plasma 11-dehydrothromboxane B2. Thromb Res 63 331-341 (1991).
4  Catella, F., Healy, D., Lawson, J.A., et al. 11-dehydro Thromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proc Natl Acad Sci USA 83 5861-5865 (1986).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
25 µg €174.00
50 µg €303.00
100 µg €575.00
500 µg €2,571.00
Pricing updated 2010-09-09.
Prices are subject to change without notice.