20150  14,15-dehydro Leukotriene B4

14,15-dehydro LTB4 (CAS 114616-11-4)



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• See more Receptor Biochemistry; Leukotrienes; Receptor Antagonist; Allergy/Asthma; Inflammation

For active pharmaceutical ingredients (APIs) related to 14,15-dehydro Leukotriene B4, see Cayman Pharma

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.1,2 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.3,4 At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM.5 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.6
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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
25 µg €129.00
50 µg €244.00
100 µg €462.00
500 µg €2,055.00
Pricing updated 2013-06-19.
Prices are subject to change without notice.