For active pharmaceutical ingredients (APIs) related to 14,15-
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-
1 Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).
2 McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. J Biol Chem 260 12832-12837 (1985).
3 Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Crit Rev Immunol 10 1-12 (1990).
4 McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents Actions 24 114-119 (1988).
5 Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. J Biol Chem 275 40686-40694 (2000).
6 Shimazaki, T., Kobayashi, Y., Sato, F., et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-
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