19023  AH 23848 (calcium salt, hydrate)



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• See more Receptor Antagonist; Atherosclerosis; Bone-Related Research; Cancer; Inflammation

For active pharmaceutical ingredients (APIs) related to AH 23848 (calcium salt, hydrate), see Cayman Pharma

Thromboxane (TXA2) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. AH-23848 is a dual antagonist of TP1 and EP4 receptors.2 It originally was found to inhibit TXA2-induced platelet aggregation (IC50 = 0.26 μM)1 and the contraction of human bronchial smooth muscle induced by the TP agonist U-46619.3 AH-23848 was subsequently demonstrated to impair PGE2-mediated relaxation of piglet saphenous vein by antagonizing the PGE2 receptor EP4.2 By inhibiting EP4, it likewise suppresses serum-induced cAMP generation, cyclin A synthesis, and the proliferation of fibroblasts4, as well as reduces metastasis in a murine model of metastatic breast cancer.5
1  Brittain, R.T., Boutal, L., Carter, M.C., et al. AH23848: A thromboxane receptor-blocking drug that can clarify the pathophysiologic role of thromboxane A2. Circulation 72 1208-1218 (1985).
2  Coleman, R.A., Grix, S.P., Head, S.A., et al. A novel inhibitory prostanoid receptor in piglet saphenous vein. Prostaglandins 47 151-168 (1994).
3  Coleman, R.A., Sheldrick, R.L.G. Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptors. Br J Pharmacol 96 688-692 (1989).
4  Sanchez, T., Moreno, J.J. Role of EP1 and EP4 PGE2 subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation. Am J Physiol Cell Physiol 282 C280-C288 (2002).
5  ma, X., Kundu, N., Rifat, S., et al. Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. Cancer Res 66(6) 2923-2927 (2006).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
1 mg €41.00
5 mg €184.00
10 mg €327.00
25 mg €714.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.

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