18570  15-deoxy-Δ12,14-Prostaglandin J2

15-deoxy-Δ12,14-PGJ2 (CAS 87893-55-8)



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• See more Nuclear Receptors; PPAR; Prostaglandins; Atherosclerosis; Endocrinology; Metabolism

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15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1
1  Kliewer, S.A., Lenhard, J.M., Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813-819 (1995).
2  Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ Cell 83, 803-812 (1995).

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Pricing Information

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Size Price Quantity
100 µg €18.00
500 µg €68.00
1 mg €108.00
5 mg €406.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.