160140  Prostaglandin E Synthase-1 (microsomal) Polyclonal Antibody

MGST1-L1; Membrane-Associated PGES-1; PIG12; Prostaglandin H/E Isomerase; mPGE Synthase-1; mPGES-1

Host: rabbit · Application(s): IHC and WB · Prostaglandin E Synthase-1 (PGES-1) catalyzes the isomerization of PGH2 (Item No. 17020) to PGE2 (Item No. 14010). PGE2 is one of the primary COX products of arachidonic acid (Item No. 90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.1,2,3,4 PGES-1 is a 16 kDa membrane-associated protein with glutathione-dependent activity.5 The mRNA is for PGES-1 is expressed in a variety of tissues including prostate, testes, and small intestine, as well as in A549 and HeLa cells.5 PGES-1 protein expression is increased in A549 cells following treatment with IL-5
1  A. L. Willis and M. Cornelsen. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3 353-357 (1973).
2  G. M. Jackson, H. T. Sharp and M. W. Varner. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. American Journal of Obstetics and Gynecology 171 1092-1096 (1994).
3  A. Robert, J. R. Schultz, J. E. Nezamis, et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70 359-370 (1976).
4  P. Arvind, E. D. Papavassiliou, G. J. Tsioulias, et al. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34 5604-5609 (1995).
5  P. J. Jakobsson, S. Thorén, R. Morgenstern, et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proceedings of the National Academy of Sciences of the United States of America 96 7220-7225 (1999).

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