13925  IκBα (cleavage specific) Monoclonal Antibody (Clone 5D1623)



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• See more Western Blot; Antibodies; NF-κB; Apoptosis; Immunology; Inflammation

For active pharmaceutical ingredients (APIs) related to IκBα (cleavage specific) Monoclonal Antibody (Clone 5D1623), see Cayman Pharma

Antigen: synthetic peptide corresponding to the caspase-3 mediated cleavage site of IκBα · Clone designation: 5D1623 · Host: mouse · Isotype: IgG1 · Application(s): WB · NF-κB is silenced in the cytoplasm by an inhibitory protein IκB.1 Synthesis of IκBα is autoregulated.2 IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.3,4,5,6 External stimuli such as tumor necrosis factor or other cytokines induce phosphorylation and degradation of IκB releasing NF-κB dimers. NF-κB dimers subsequently translocate to the nucleus and activate target genes. Six members of the IκB family have been identified.1 IκBa can be cleaved by caspases during apoptosis to produce an amino-terminal truncated IκBa (ΔN-IκBα).7,8 The ΔN-IκBα is resistant to degradation in response to inducers of NF-κB and act as a dominant inhibitory molecule that suppresses NF-κB activity during apoptosis.
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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Warning This product is not for human or veterinary use.

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Pricing updated 2013-05-25.
Prices are subject to change without notice.