13919  IκBα Polyclonal Antibody (aa 34-48)

For active pharmaceutical ingredients (APIs) related to IκBα Polyclonal Antibody (aa 34-48), see Cayman Pharma

Antigen: synthetic peptide corresponding to human IκBα amino acids 34-48 · Host: rabbit · Application(s): WB · NF-κB is silenced in the cytoplasm by an inhibitory protein IkB.1 Synthesis of IκBα is autoregulated.2 IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.3,4,5,6 External stimuli such as tumor necrosis factor or other cytokines induce phosphorylation and degradation of IκB releasing NF-κB dimers. NF-κB dimers subsequently translocate to the nucleus and activate target genes. Six members of the IkB family members have been identified.1 One of the first genes induced following NF-κB activation is IκBα.
1  Verma, I.M., Stevenson, J.K., Schwarz, E.M., et al. Rel/NF-κB/IκB family: Intimate tales of association and dissociation. Genes Dev 9 2723-2735 (1995).
2  Verma, I.M., and Stevenson, J. IκB kinase: Beginning, not the end. Proc Natl Acad Sci USA 94 11758-11760 (1997).
3  DiDonato, J.A., Hayakawa, M., Rothwarf, D.M., et al. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388 548-554 (1997).
4  Régnier, C.H., Song, H.Y., Gao, X., et al. Identification and characterization of an IκB kinase. Cell 90 373-383 (1997).
5  Mercurio, F., Zhu, H., Murray, B.W., et al. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation. Science 278(5339) 860-866 (1997).
6  Yamaoka, S., Courtois, G., Bessia, C., et al. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93 1231-1240 (1998).

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Pricing updated 2014-04-19.
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