13907  Caspase-1 Monoclonal Antibody (Clone 14F468)

IL-1β Converting Enzyme



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• See more Immunohistochemistry; Western Blot; Antibodies; Apoptosis; Inflammation

For active pharmaceutical ingredients (APIs) related to Caspase-1 Monoclonal Antibody (Clone 14F468), see Cayman Pharma

Antigen: synthetic peptide corresponding to human Caspase-1 within the region of amino acids 371-390 · Clone designation: 14F468 · Host: mouse · Isotype: IgG1κ · Application(s): IHC (paraffin-embedded sections) and WB · Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.1 The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1 is similar to the cell death gene CED-3 of C. elegans and regulates multiple proinflammatory cytokines, including interleukin-1β and interferon-γ-inducing factor.
1  Cerretti, D.P., Kozlosky, C.J., Mosley, B., et al. Molecular cloning of the interleukin-1β converting enzyme. Science 256 97-100 (1992).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Pricing updated 2010-09-09.
Prices are subject to change without notice.