13755  NF-κB (p50) Monoclonal Antibody (Clone 2J10D7)



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• See more Immunohistochemistry; Western Blot; Antibodies; NF-κB; Cancer; Immunology; Inflammation; Signal Transduction

For active pharmaceutical ingredients (APIs) related to NF-κB (p50) Monoclonal Antibody (Clone 2J10D7), see Cayman Pharma

Antigen: a portion of amino acids 150-200 of human NF-κB (p50) · Clone designation: 2J10D7 · Isotype: IgG1κ · Application(s): IHC and WB · NF-κB is a transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis, and inflammation. NF-κB1 (p50), a 50 kDa functional sub-unit of NF-κB, is a member of the Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing a nuclear localization signal, DNA-binding and dimerization domains. NF-κB (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-κB factor. NF-κB (p50) directs the nuclear translocation of NF-κB and is instrumental in its DNA-binding. A pathological role of NF-κB has been suggested in AIDS, hematogenic cancer cell metastasis, and rheumatoid arthritis.

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Warning This product is not for human or veterinary use.

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Pricing updated 2010-03-11.
Prices are subject to change without notice.