13748  MyD88 Homodimerization Inhibitory Peptide Set

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MyD88 is an adapter protein that links toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) with downstream signaling molecules. Homodimerization of MyD88 is a critical step in the signaling process and allows the recruitment and activation of the kinase IRAK. MyD88 exists as a homodimer when recruited to activate TLR/IL-receptors (TIR). The inhibitor peptide contains a sequence from the MyD88 TIR homodimerization domain.1 MyD88 monomer binds to this inhibitor peptide, thereby blocking Myd88 homodimerization. The MyD88 homodimerization inhibitory peptide contains a protein transduction (PTD) sequence (DRQIKIWFQNRRMKWKK) derived from antennapedia which renders the peptide cell permeable.2 The control peptide consists of only the PTD sequence.
1  Loiarro, M., Sette, C., Gallo, G., et al. Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-kB. J Biol Chem 280(16) 15809-15814 (2005).
2  Derossi, D., Joliot, A.H., Chassaing, G., et al. The third helix of the antennapedia homeodomain translocates through biological membranes. J Biol Chem 269(14) 10444-10450 (1994).

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Pricing Information

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2 mg €476.00
5 mg €1,082.00
Pricing updated 2010-03-12.
Prices are subject to change without notice.

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