13498  ARRB2 Peptide Affinity-purified Polyclonal Antibody

β-Arrestin-2



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• See more Immunohistochemistry; Western Blot; Antibodies; Cell Biology; Signal Transduction

For active pharmaceutical ingredients (APIs) related to ARRB2 Peptide Affinity-purified Polyclonal Antibody, see Cayman Pharma

Antigen: synthetic peptide from human ARRB2 within the region of amino acids 15-50 · Host: rabbit · Application(s): WB and IHC · β-Arrestin-2 (ARRB2) is an adaptor protein belonging to the arrestin family with an N-arrestin domain and a C-arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate β-adrenergic receptor A function, thus enhancing β2AR receptor mediated nuclear translocation of ERK. It binds to phosphorylated β-adrenergic receptors, thereby causing a significant impairment of their capacity to activate Gs proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Pricing updated 2010-08-01.
Prices are subject to change without notice.