13486  LSD1 Polyclonal Antibody (aa 450-500)



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• See more Western Blot; Antibodies; Demethylase; Cancer; Chromatin Research; Epigenetics; Histone Modification

For active pharmaceutical ingredients (APIs) related to LSD1 Polyclonal Antibody (aa 450-500), see Cayman Pharma

Antigen: synthetic peptide from human LSD1 amino acids 450-500 · Host: rabbit · Application(s): WB · LSD1, the first known lysine-specific histone demethylase, is an 886 amino acid nuclear protein belonging to flavin monoamine oxidase family. It contains a SWIRM domain, a FAD-binding motif and an amine oxidase domaine. This protein is ubiquitously expressed and is a component of several histone deacetylase complexes. LSD1 acts as a component of the CoREST and other transcriptional co-repressor complexes and also plays an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (might use alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer.

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Warning This product is not for human or veterinary use.

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Pricing updated 2013-05-24.
Prices are subject to change without notice.