Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-
1 Maclouf, J.A., and Murphy, R.C. Transcellular metabolism of neutrophil-
2 Piper, P.J. Formation and actions of leukotrienes. Physiol Rev 64 744-761 (1984).
3 Campbell, B.J., Baker, S.F., Shukla, S.D., et al. Bioconversion of leukotriene D4 by lung dipeptidase. Biochim Biophys Acta 1042 107-112 (1990).
4 Gareau, Y., Zamboni, R., and Wong, A.W. Total synthesis of N-
5 Yan, D., Stocco, R., Sawyer, N., et al. Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT2) agonist, N-
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