Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-
1 J. A. Maclouf and R. C. Murphy. Transcellular metabolism of neutrophil-
2 P. J. Piper. Formation and actions of leukotrienes. Physiological Reviews 64 744-761 (1984).
3 B. J. Campbell, S. F. Baker, S. D. Shukla, et al. Bioconversion of leukotriene D4 by lung dipeptidase. Biochimica et Biophysica Acta 1042 107-112 (1990).
4 Y. Gareau, R. Zamboni and A. W. Wong. Total synthesis of N-
5 D. Yan, R. Stocco, N. Sawyer, et al. Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT2) agonist, N-
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