13369  tetranor-PGAM

tetranor-Prostaglandin A Metabolite (CAS 52510-53-9)




Prostaglandin E2 (PGE2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness. However due to its rapid metabolism, direct measurement of PGE2 in biological samples is difficult. The major urinary metabolite of PGE2, tetranor-PGEM, serves as an indirect marker of PGE2 biosynthesis.1,2 Though like PGE2, tetranor-PGEM is also chemically unstable. tetranor-PGAM is a dehydration product of tetranor-PGEM and can be measured as a surrogate for tetranor-PGEM levels in urine.3
1  Hamberg, M. Inhibition of prostaglandin synthesis in man. Biochem Biophys Res Commun 49 720-726 (1972).
2  missing reference text
3  Neale, J.R., and Dean, B.J. Liquid chromatography-tandem mass spectrometric quantification of the dehydration product of tetranor PGE-M, the major urinary metabolite of prostaglandin E2 in human urine. J Chromatogr B Analyt Technol Biomed Life Sci 871(1) 72-77 (2008).

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25 µg €120.00
50 µg €228.00
100 µg €432.00
Pricing updated 2014-11-24.
Prices are subject to change without notice.