13369  tetranor-PGAM

tetranor-Prostaglandin A Metabolite (CAS 52510-53-9)

Prostaglandin E2 (PGE2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness. However due to its rapid metabolism, direct measurement of PGE2 in biological samples is difficult. The major urinary metabolite of PGE2, tetranor-PGEM, serves as an indirect marker of PGE2 biosynthesis.1,2 Though like PGE2, tetranor-PGEM is also chemically unstable. tetranor-PGAM is a dehydration product of tetranor-PGEM and can be measured as a surrogate for tetranor-PGEM levels in urine.3
1  M. Hamberg. Inhibition of prostaglandin synthesis in man. Biochemical and Biophysical Research Communications 49 720-726 (1972).
2  missing reference text
3  J. R. Neale and B. J. Dean. Liquid chromatography-tandem mass spectrometric quantification of the dehydration product of tetranor PGE-M, the major urinary metabolite of prostaglandin E2 in human urine. Journal of Chromatography.B, Analytical Technologies in the Biomedical and Life Sciences 871(1) 72-77 (2008).

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25 µg €125.00
50 µg €238.00
100 µg €450.00
Pricing updated 2017-01-19.
Prices are subject to change without notice.