Prostaglandin E2 (PGE2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness. However due to its rapid metabolism, direct measurement of PGE2 in biological samples is difficult. The major urinary metabolite of PGE2, tetranor-
1 Hamberg, M. Inhibition of prostaglandin synthesis in man. Biochem Biophys Res Commun 49 720-726 (1972).
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3 Neale, J.R., and Dean, B.J. Liquid chromatography-
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