Prostaglandin E2 (PGE2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness. However due to its rapid metabolism, direct measurement of PGE2 in biological samples is difficult. The major urinary metabolite of PGE2, tetranor-
1 M. Hamberg. Inhibition of prostaglandin synthesis in man. Biochem. Biophys. Res. Commun. 49 720-726 (1972).
2 missing reference text
3 J. R. Neale and B. J. Dean. Liquid chromatography-
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