13320  MCI-186

Edaravone; NSC 2629 (CAS 89-25-8)

MCI-186 is a free radical scavenger with diverse protective effects in vivo. Most notably, it reduces damage due to ischemia-reperfusion injury in lung, liver, and brain in animal models of transplant, infection, traumatic brain injury, and stroke.1,2,3,4 MCI-186 provides these protective effects, at least in part, by reducing reactive oxygen species, inhibiting apoptosis, and blocking nonenzymatic peroxidation and lipoxygenase activity.3,5,6
1  J. z. Xu, B. z. Shen, Y. Li, et al. Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model. Chinese Medical Journal 121(16) 1583-1587 (2008).
2  H. Kono, M. Asakawa, H. Fujii, et al. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. Journal of Pharmacology and Experimental Therapeutics 307(1) 74-82 (2003).
3  Y. Gao, X. s. Ding, S. Xu, et al. Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage. Chinese Medical Journal 122(16) 1935-1940 (2009).
4  K. Kikuchi, K. i. Kawahara, S. Tancharoen, et al. The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. Journal of Pharmacology and Experimental Therapeutics 329(3) 865-874 (2009).
5  K. G. Rajesh, S. Sasaguri, R. Suzuki, et al. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. American Journal of Physiology.Heart and Circulatory Physiology 285 H2171-H2178 (2003).
6  K. Abe, S. Yuki and K. Kogure. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19 480-485 (1988).

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100 g €25.00
500 g €43.00
Pricing updated 2017-01-19.
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