13320  MCI-186

Edaravone; NSC 2629 (CAS 89-25-8)




MCI-186 is a free radical scavenger with diverse protective effects in vivo. Most notably, it reduces damage due to ischemia-reperfusion injury in lung, liver, and brain in animal models of transplant, infection, traumatic brain injury, and stroke.1,2,3,4 MCI-186 provides these protective effects, at least in part, by reducing reactive oxygen species, inhibiting apoptosis, and blocking nonenzymatic peroxidation and lipoxygenase activity.5,6,3
1  Xu, J., Shen, B., Li, Y., et al. Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model. Chin Med J 121(16) 1583-1587 (2008).
2  Kono, H., Asakawa, M., Fujii, H., et al. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther 307(1) 74-82 (2003).
3  Gao, Y., Ding, X., Xu, S., et al. Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage. Chin Med J 122(16) 1935-1940 (2009).
4  Kikuchi, K., Kawahara, K., Tancharoen, S., et al. The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. J Pharmacol Exp Ther 329(3) 865-874 (2009).
5  Rajesh, K.G., Sasaguri, S., Suzuki, R., et al. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol 285 H2171-H2178 (2003).
6  Abe, K., Yuki, S., and Kogure, K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19 480-485 (1988).

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5 g €21.00
100 g €24.00
500 g €41.00
Pricing updated 2014-07-23.
Prices are subject to change without notice.