13265  4-hydroxy Nonenal Alkyne

Click Tag™ 4-HNE alkyne (CAS 1011268-23-7)



• See below for pricing and ordering
• See more Click Chemistry; Oxylipins; Atherosclerosis; Cancer; Diabetes; Inflammation; Neuroscience; Oxidative Injury

For active pharmaceutical ingredients (APIs) related to 4-hydroxy Nonenal Alkyne, see Cayman Pharma

4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.1,2 It is considered a potential causal agent in numerous diseases, including chronic inflammation, neurodegenerative diseases, atherosclerosis, diabetes, and cancer, in part because it covalently modifies DNA and proteins resulting in genetic mutations and altered cell signaling, respectively.3 4-HNE Alkyne is a form of 4-HNE with a terminal alkyne. Such terminal alkyne groups can be used in linking reactions, known as ‘click chemistry,’ characterized by high dependability and specificity of azide-alkyne bioconjugation reactions.4,5 Click chemistry has only recently been applied to the study of oxidized lipids.6
1  Pryor, W.A., Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic Biol Med 8 541-543 (1990).
2  Esterbauer, H., Schaur, R.J., Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic Biol Med 11 81-128 (1991).
3  West, J.D., Marnett, L.J. Endogenous reactive intermediates as modulators of cell signaling and cell death. Chem Res Toxicol 19(2) 173-194 (2006).
4  Kolb, H.C., Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discov Today 8(24) 1128-1137 (2003).
5  Lutz, J., Zarafshani, Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne “click” chemistry. Adv Drug Deliv Rev 60 958-970 (2008).
6  Vila, A., Tallman, K.A., Jacobs, A.T., et al. Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. Chem Res Toxicol 21(2) 432-444 (2008).

Download Product Insert 124 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Item total €0.00
Shopping cart total €0.00
Size Price Quantity
100 µg €48.00
500 µg €216.00
1 mg €384.00
5 mg €1,680.00
Pricing updated 2010-09-09.
Prices are subject to change without notice.