13178  Salermide

(CAS 1105698-15-4)



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• See more Inhibitors; Cancer; Gene Regulation

For active pharmaceutical ingredients (APIs) related to Salermide, see Cayman Pharma

The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis.1,2 Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death.3 In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~ 20 μM) by reactivating proapototic genes that are repressed by SIRT1.3
1  Yamamoto, H., Schoonjans, K., Auwerx, J. Sirtuin functions in health and disease. Mol Endocrinol 21(8) 1745-1755 (2007).
2  Milne, J.C., Denu, J.M. The sirtuin family:Therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 12 11-17 (2008).
3  Lara, E., Mai, A., Calvanese, V., et al. Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene (2008).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
5 mg €30.00
10 mg €58.00
50 mg €240.00
100 mg €420.00
Pricing updated 2010-09-09.
Prices are subject to change without notice.