13130  trans-Resveratrol-d4

(E)-Resveratrol-d4 (CAS 1089051-56-8)




trans-Resveratrol-d4 contains four deuterium atoms at the 2, 3, 5, and 6 positions. It is intended for use as an internal standard for the quantification of trans-resveratrol by GC- or LC-mass spectrometry. Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.1,2,3 trans-Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.4 trans-Resveratrol is also a selective inhibitor of cyclooxygenase 1 (COX-1).5 It inhibits COX and peroxidase activities of COX-1 with ED50 values of 15 and 3.7 µM, respectively, with essentially no inhibition of the COX activity of COX-2.
1  Frémont, L., Belguendouz, L., and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci 64 2511-2521 (1999).
2  Johnson, J.L., and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat 56 131-143 (1998).
3  Rotondo, S., Rajtar, G., Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br J Pharmacol 123 1691-1699 (1998).
4  Miller, N.J., and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clin Chem 41 1789 (1995).
5  Jang, M., Cai, L., Udeani, G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 218-220 (1997).

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Size Price Quantity
100 µg €47.00
250 µg €112.00
500 µg €212.00
1 mg €375.00
Pricing updated 2014-12-22.
Prices are subject to change without notice.