13060  17(R)-Resolvin D1

AT-RvD1; Aspirin-triggered-Resolvin D1; 17(R)-RvD1 (CAS 528583-91-7)



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• See more Lipoxins; Immunology; Inflammation

For active pharmaceutical ingredients (APIs) related to 17(R)-Resolvin D1, see Cayman Pharma

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.1 17(R)-Resolvin D1 is an aspirin-triggered epimer of resolvin D1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to resolvin D1 (EC50 ~30 nM).3 17(R)-Resolvin D1 exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.3 In contrast to resolvin D1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases.
1  Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 278(17) 14677-14687 (2003).
2  Ariel, A., Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. Trends Immunol 28(4) 176-183 (2007).
3  Sun, Y., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem 282(13) 9323-9334 (2007).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
10 µg €146.00
25 µg €345.00
50 µg €654.00
100 µg €1,162.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.