13021  2-Methoxyestradiol

Panzem; NSC 659853; 2-ME2; 2-Hydroxyestradiol 2-methyl ether (CAS 362-07-2)



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2-methoxy Estradiol (2-ME2) is a natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. Administration of 2-hydroxy estradiol (2-HE2) to rats results in formation and clearance of 2-ME2 with t½ values of 7.9 and 24.9 minutes, respectively.1 2-ME2 exhibits no affinity for estrogen receptors. 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1a pathway.2,3,4 The levels of COMT and 2-ME2 are significantly lower in women with severe pre-eclampsia.5
1  Zacharia, L.C., Piché, C.A., Fielding, R.M., et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. J Pharmacol Exp Ther 309(3) 1093-1097 (2004).
2  Mooberry, S.L. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Curr Opin Oncol 15 425-430 (2003).
3  Mooberry, S.L. Mechanism of action of 2-methoxyestradiol: New developments. Drug Resist Updat 6 355-361 (2003).
4  Becker, C.M., Rohwer, N., Funakoshi, T., et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1a and suppressess growth of lesions in a mouse model of endometriosis. Am J Pathol 172(2) 534-544 (2008).
5  Kanasaki, K., Palmsten, K., Sugimoto, H., et al. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature 453 1117-1123 (2008).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
5 mg €28.00
10 mg €53.00
25 mg €125.00
50 mg €221.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.