11548  BRDT bromodomain 1 (human recombinant)

BRD-containing protein testis specific; Cancer/testis antigen 9; RING3-like protein; CT9; BRD6



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For active pharmaceutical ingredients (APIs) related to BRDT bromodomain 1 (human recombinant), see Cayman Pharma

Source: recombinant N-terminal GST-tagged protein expressed in E. coli · Mr: 40.6 kDa · The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.1 These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters.2 The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT.3 The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions.4,5,6 BRDT is similar to the RING3 protein family and possesses 2 bromodomain motifs and a PEST sequence motif, which is a region rich in proline (P), glutamic acid (E), serine (S), and threonine (T) residues known to have a short intracellular half-life. This product contains the bromodomain 1 region of BRDT.
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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
25 µg €125.00
50 µg €238.00
100 µg €449.00
Pricing updated 2013-05-24.
Prices are subject to change without notice.