11164  5-Azacytidine

Ladakamycin; 5-AzaC; NSC 103-627; U 18496; WR 183027; NSC 102816; Mylosar; Antibiotic U 18496 (CAS 320-67-2)



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• See more Antibiotic; Inhibitors; Cancer; Epigenetics; Gene Regulation

For active pharmaceutical ingredients (APIs) related to 5-Azacytidine, see Cayman Pharma

5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes.1 It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines).2,3,4 5-Azacytidine has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases.1
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Download Product Insert 133 Kb PDF
Download Material Safety Data Sheet (MSDS) 30 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

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Size Price Quantity
50 mg €18.00
100 mg €35.00
250 mg €82.00
Pricing updated 2013-05-23.
Prices are subject to change without notice.