11071  BRD2 bromodomain 1 (human recombinant; GST-tagged)

RING3; Bromodomain containing 4; RNF3



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• See more Protein Binding; Proteins; Recombinant Proteins; Cancer; Chromatin Research; Epigenetic Readers; Epigenetics; Gene Regulation; Infectious Disease; Inflammation

For active pharmaceutical ingredients (APIs) related to BRD2 bromodomain 1 (human recombinant; GST-tagged), see Cayman Pharma

Source: recombinant N-terminal GST-tagged protein expressed in E. coli · Mr: 42.4 kDa · The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.1 These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT.2 The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions.3,4,5 The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.6,7,8,9,4 Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.10,11,12
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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Warning This product is not for human or veterinary use.

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Size Price Quantity
25 µg €125.00
50 µg €238.00
100 µg €449.00
Pricing updated 2013-05-19.
Prices are subject to change without notice.