11050  Concanamycin A

Antibiotic X 4357B; NSC 674620; X 4357B (CAS 80890-47-7)


The vacuolar H+-ATPase (V-ATPase) is a multisubunit complex that establishes pH gradients along secretory and endocytic pathways by catalyzing ATP hydrolysis via the V1 domain and driving proton translocation through the V0 domain.1 Concanamycin A is a plecomacrolide antibiotic produced by Streptomyces that blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50 = 2.1-2.3 μM).2,3,4 Concanamycin A blocks cell surface expression of viral glycoproteins without affecting their synthesis and, at 0.8 μM, prevents entry of influenza virus into cells.5
1  M. Huss and H. Wieczorek. Inhibitors of V-ATPases: Old and new players. Journal of Experimental Biology 212 341-346 (2009).
2  J. A. Sobota, N. Bäck, B. A. Eipper, et al. Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. Journal of Cell Science 122(19) 3542-3553 (2009).
3  R. M. Johnson, C. Allen, S. D. Melman, et al. Identification of inhibitors of V-ATPase pumps in yeast by HTS flow cytometry. Analytical Biochemistry 398(2) 203-211 (2010).
4  S. Dröse and K. Altendorf. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. Journal of Experimental Biology 200 1-8 (1997).
5  R. Guinea and L. Carrasco. Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells. Journal of Virology 69(4) 2306-2312 (1995).

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25 µg €90.00
100 µg €206.00
1 mg €684.00
Pricing updated 2016-10-01.
Prices are subject to change without notice.