11050  Concanamycin A

Antibiotic X 4357B; NSC 674620; X 4357B (CAS 80890-47-7)




The vacuolar H+-ATPase (V-ATPase) is a multisubunit complex that establishes pH gradients along secretory and endocytic pathways by catalyzing ATP hydrolysis via the V1 domain and driving proton translocation through the V0 domain.1 Concanamycin A is a plecomacrolide antibiotic produced by Streptomyces that blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50 = 2.1-2.3 μM).2,3,4 Concanamycin A blocks cell surface expression of viral glycoproteins without affecting their synthesis and, at 0.8 μM, prevents entry of influenza virus into cells.5
1  Huss, M., and Wieczorek, H. Inhibitors of V-ATPases: Old and new players. J Exp Biol 212 341-346 (2009).
2  Sobota, J.A., Bäck, N., Eipper, B.A., et al. Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. J Cell Sci 122(19) 3542-3553 (2009).
3  Johnson, R.M., Allen, C., Melman, S.D., et al. Identification of inhibitors of V-ATPase pumps in yeast by HTS flow cytometry. Anal Biochem 398(2) 203-211 (2010).
4  Dröse, S., and Altendorf, K. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J Exp Biol 200 1-8 (1997).
5  Guinea, R., and Carrasco, L. Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells. J Virol 69(4) 2306-2312 (1995).

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25 µg €94.00
100 µg €225.00
Pricing updated 2014-11-21.
Prices are subject to change without notice.