11050  Concanamycin A

Antibiotic X 4357B; X 4357B; NSC 674620 (CAS 80890-47-7)



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The vacuolar H+-ATPase (V-ATPase) is a multisubunit complex that establishes pH gradients along secretory and endocytic pathways by catalyzing ATP hydrolysis via the V1 domain and driving proton translocation through the V0 domain.1 Concanamycin A is a plecomacrolide antibiotic produced by Streptomyces that blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50 = 2.1-2.3 μM).2,3,4 Concanamycin A blocks cell surface expression of viral glycoproteins without affecting their synthesis and, at 0.8 μM, prevents entry of influenza virus into cells.5
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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Warning This product is not for human or veterinary use.

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25 µg €119.00
100 µg €428.00
Pricing updated 2013-06-20.
Prices are subject to change without notice.

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