10873  TRAF5 Monoclonal Antibody (Clone 55A219)

Clone designation: 55A219 · Host: mouse · Application(s): WB · Tumor necrosis factor (TNF)-induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor-associated factors (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have led to identification of seven TRAFs (TRAF1-TRAF7).1,2,3,4,5 Human TRAF5 is a 557-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-β receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation.5
1  H. Nakano, S. Sakon, H. Koseki, et al. Targeted disruption of traf5 gene causes defects in CD40-and CD27-mediated lymphocyte activation. Proceedings of the National Academy of Sciences of the United States of America 96(17) 9803-9808 (1999).
2  Z. Cao, J. Xiong, M. Takeuchi, et al. TRAF6 is a signal transducer for interleukin-1. Nature 383 443-446 (1996).
3  M. Rothe, S. C. Wong, W. J. Henzel, et al. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor. Cell 78(4) 681-692 (1994).
4  G. Cheng, A. M. Cleary, Z. S. Ye, et al. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267(5203) 1494-1498 (1995).
5  H. Nakano, H. Oshima, W. Chung, et al. TRAF5, an activator of NF-κB and putative signal transducer for the lymphotoxin-β receptor. The Journal of Biological Chemisty 271(25) 14661-14664 (2011).

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