10873  TRAF5 Monoclonal Antibody (Clone 55A219)



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• See more Western Blot; Antibodies; Apoptosis; Inflammation; Signal Transduction

For active pharmaceutical ingredients (APIs) related to TRAF5 Monoclonal Antibody (Clone 55A219), see Cayman Pharma

Antigen: fusion protein corresponding to amino acids 77-186 of human TRAF5 · Clone designation: 55A219 · Host: mouse · Application(s): WB · Tumor necrosis factor (TNF)-induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor-associated factors (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have led to identification of seven TRAFs (TRAF1-TRAF7).1,2,3,4,5 Human TRAF5 is a 557-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-β receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation.5
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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Pricing updated 2013-05-19.
Prices are subject to change without notice.