10336  JMJD2A (human recombinant)

Jumonji Domain Containing 2A; KDM4A; JHDM3A



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• See more Enzyme Activity; Demethylase; Enzymes; Proteins; Recombinant Proteins; Cancer; Chromatin Research; Epigenetics; Gene Regulation; Histone Modification

For active pharmaceutical ingredients (APIs) related to JMJD2A (human recombinant), see Cayman Pharma

Source: active recombinant N-terminal His-tagged protein expressed in E. coli · Mr: 43 kDa · Methylation of lysine residues of core histones plays a critical role in the regulation of gene expression.1 Jumonji domain containing 2A (JMJD2A) is the first reported trimethyllysine-specific histone demethylase.2 It catalyzes the demethylation of trimethylated histone at lysine residues 9 and 36.3 Like other JmjC protein hydroxylase family members, JMJD2A is an α-ketoglutarate-dependent Fe (II) oxygenase.3 JMJD2A’s transcriptional function appears to depend on protein associations, as it is implicated in both transcriptional silencing and upregulation of the androgen receptor-dependent genes.2 Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylases may be drug discovery targets for therapeutic intervention.1
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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
25 µg €111.00
50 µg €210.00
100 µg €398.00
Pricing updated 2013-05-25.
Prices are subject to change without notice.