10317  SIRT4 (human recombinant)

sir4; Sirtuin 4; SIR2L4



• See below for pricing and ordering
• See more Enzyme Activity; Proteins; Recombinant Proteins; Chromatin Research; Epigenetics; Histone Modification

For active pharmaceutical ingredients (APIs) related to SIRT4 (human recombinant), see Cayman Pharma

Source: Recombinant N-terminal GST-tagged SIRT4 purified from E. coli · Mr: 61.9 kDa · There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1-SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent deacetylase and APD-ribosyltransferase activities. SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the transfer of ADP-ribose from NAD to specific substrates such as glutamate dehydrogenase (GDH).1 In caloric-sufficient conditions, SIRT4 ADP-ribosylates GDH, repressing its activity and correspondingly decreasing insulin secretion.2 There is some uncertainty about the relevance of sirtuin ribosyl transferase activity due to its very slow rate, which is about 500 times lower than the corresponding deacetylation reaction (for those that have been characterized).3 SIRT4 is found in many tissues, but is specifically enriched in the kidney, heart, brain, and liver. 2
1  Ahuja, N., Schwer, B., Carobbio, S., et al. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem 282(46) 33583-33592 (2007).
2  Haigis, M.C., Mostoslavsky, R., Haigis, K.M., et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic β cells. Cell 126 941-954 (2006).
3  Du, J., Jiang, H., Lin, H. Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry 48 2878-2890 (2009).

Download Product Insert 199 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Item total €0.00
Shopping cart total €0.00
Size Price Quantity
25 µg €101.00
50 µg €192.00
100 µg €363.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.