10279  PAF Acetylhydrolase (human recombinant)

Lp-PLA2; PAF-AH; Platelet-Activating Factor Acetylhydrolase; Lipoprotein PLA2



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• See more Enzyme Activity; Inhibitor Screening Assay; Enzymes; Proteins; Recombinant Proteins; Inflammation

For active pharmaceutical ingredients (APIs) related to PAF Acetylhydrolase (human recombinant), see Cayman Pharma

Source: recombinant N-terminal His-tagged protein purified from E. coli · Mr: 46.4 kDa · Platelet-activating factor (PAF) is an important lipid mediator involved in inflammation. Platelet-activating factor acetylhydrolase (PAF-AH) is an extracellular phospholipase A2 which hydrolyzes the acetyl group at the sn-2 position of phospholipids.1 Two main types of PAF-AH have been characterized, namely the secreted (i.e. plasma) and intracellular enzymes, which are encoded on individual genes and share only 41% homology at the amino acid level.2,3 PAF deacetylation by PAF-AH causes loss of biological activity, making PAF-AH potential useful as an anti-inflammation therapy. Human recombinant PAF-AH was characterized using 2-Thio PAF as a substrate, which upon hydrolysis by PAF-AH releases a free thiol that reacts with 5,5-dithio-bis(2-dinitrobenzoic acid) (DTNB) to produce 5-thio-2-nitrobenzoic acid (TNB) with an absorbance maximum at 412 nm.
1  Tjoelker, L.W., Wilder, C., Eberhardt, C., et al. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature 374 549-553 (1995).
2  Stafforini, D.M., McIntyre, T.M., Zimmerman, G.A., et al. Platelet-activating factor acetylhydrolases. J Biol Chem 272 17895-17898 (1997).
3  missing reference text

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
25 µg €180.00
50 µg €342.00
100 µg €648.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.