10277  ATB-337



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• See more Hydrogen Sulfide Donor; Hydrogen Sulfide; Inflammation

For active pharmaceutical ingredients (APIs) related to ATB-337, see Cayman Pharma

Hydrogen sulfide (H2S) is a naturally occurring gasotransmitter with vasodilator and inflammatory modulating activity.1,2 Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, diclofenac, and ibuprofen, are some of the most commonly used anti-inflammatory drugs available but exhibit significant side effects, particularly gastric damage, when used chronically. ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac.3 In rats, diclofenac at 10-50 µmol/kg caused significant gastrointestinal damage, whereas no damage was observed with ATB-337 treatment at the same dose. ATB-337 at 50 µmol/kg does not promote leukocyte adherence to vascular endothelium, an effect observed with diclofenac treatment alone. COX-1 and COX-2 were inhibited with similar efficacy by diclofenac and ABT-337. An increase in expression of the pro-inflammatory mediator TNF-α, as well as, the adhesion molecules ICAM-1 and LFA-1 were not observed in rats treated with 50 µmol/kg ABT-337, effects seen with equimolar doses of diclofenac. These results indicate that H2S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than traditional NSAIDs alone.
1  Li, L., Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air?. Trends Pharmacol Sci 29(2) 84-90 (2007).
2  Wallace, J.L. Hydrogen sulfide-releasing anti-inflammatory drugs. Trends Pharmacol Sci 28(10) 501-505 (2007).
3  Wallace, J.L., Caliendo, G., Santagada, V., et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology 132 261-271 (2007).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
1 mg €36.00
5 mg €162.00
10 mg €288.00
50 mg €1,260.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.