10245  LSD1 (human recombinant)

KDM1; p110b; BHC110; Lysine-Specific Demethylase 1; NPAO; AOF2



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• See more Enzyme Activity; Demethylase; Enzymes; Proteins; Recombinant Proteins; Cancer; Chromatin Research; Epigenetics; Gene Regulation; Histone Modification

For active pharmaceutical ingredients (APIs) related to LSD1 (human recombinant), see Cayman Pharma

Source: active human recombinant N-terminal His-tagged enzyme expressed in E. coli; BC048134 · Mr: 94 kDa · LSD1 belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO).1 LSD1 is a component of several histone deacetylase co-repressor complexes, including histone deacetylases 1 and 2, CtBP, and the neuronal CoREST complexes.2 LSD1, with the help of its cofactor CoREST, specifically demethylates mono- and dimethylated histone H3 lysine 4 (H3-K4), resulting in transcriptional repression.3 In addition to demethylating histones, LSD1 controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370). 4 This activity does not seem to require CoREST and p53 demethylation of LYS370 prevents p53 interaction with its co-activator 53BP1 to induce apoptosis. 4,5,6,7
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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

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Size Price Quantity
25 units €123.00
50 units €233.00
100 units €441.00
Pricing updated 2013-05-24.
Prices are subject to change without notice.