10011670  Soluble Epoxide Hydrolase (murine recombinant from Sf21 cells)

sEH; Epoxide Hydrolase 2; EPHX2; Cytosolic Epoxide Hydrolase; CEH

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• See more Enzyme Activity; Inhibitor Screening Assay; Enzymes; Proteins; Recombinant Proteins; Hypertension; Inflammation

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Source: Murine recombinant N-terminal His-tagged protein purified from Sf21 cells · Mr: 64 kDa · Mammalian soluble epoxide hydrolase (sEH) is a member of the α/β-hydrolase fold family of enzymes that catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. sEH is a homodimer consisting of two domains.1 The C-terminal domain is responsible for the epoxide hydrolase activity while the N-terminal domain has a catalytic center with phosphatase activity. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which are known for their vasodialatory effects as well as for their anti-inflammatory actions.2 Inhibition of sEH in animal models was shown to reduce hypertension and vascular inflammation, as well as related syndromes, validating sEH as a highly promising target for drug discovery.3
1  Chiamvimonvat, N., Ho, C., Tsai, H., et al. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. J Cardiovasc Pharmacol 50(3) 225-237 (2007).
2  Yu, Z., Xu, F., Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87 992-998 (2000).
3  Imig, J.D., Zhao, X., Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(2) 975-981 (2005).

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Pricing Information

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Size Price Quantity
25 µg €180.00
50 µg €274.00
100 µg €519.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.