10011349  Dimebolin (hydrochloride)

(CAS 97657-92-6)



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• See more Inhibitors; Alzheimer's Research; Neuroscience

For active pharmaceutical ingredients (APIs) related to Dimebolin (hydrochloride), see Cayman Pharma

Dimebolin (hydrochloride), also known as Dimebon™, is an orally-available drug, approved in Russia for use as a non-selective antihistamine, that has shown promise in the treatment of neurodegenerative diseases, including Alzheimer’s disease and Huntington’s disease. 1,2,3 In addition to preventing the onset and progression of disease by being neuroprotective, Dimebolin appears to promote clinical improvement by increasing cognitive function.4,2 At the cellular level, Dimebolin appears to have diverse effects, inhibiting the neurotoxic action of β-amyloid and blocking L-type calcium channels, inhibiting NMDA-type glutamate receptors, and preventing mitochondrial leakage.5,6,7 The hydrochloride form of Dimebolin is soluble in both aqueous and organic solvents.
1  Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P., et al. Dimebon improves learning in animals with experimental Alzheimer’s disease. Bull Exp Biol Med 129(6) 640-642 (2000).
2  Doody, R.S., Gavrilova, S.I., Sano, M., et al. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer’s disease: A randomised, double-blind, placebo-controlled study. Lancet 372 207-215 (2008).
3  Wu, J., Li, Q., Bezprozvanny, I. Evaluation of dimebon in cellular model of Huntington’s disease. Mol Neurodegener (2008).
4  Bachurin, S., Bukatina, E., Lermontova, N., et al. Antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. Ann N Y Acad Sci 939 425-435 (2001).
5  Lermontova, N.N., Redkozubov, A.E., Shevtsova, E.F., et al. Dimebon and tacrine inhibit neurotoxic action of β-amyloid in culture and block L-type Ca2+ channels. Bull Exp Biol Med 132(5) 1079-1083 (2001).
6  Grigor'ev, V.V., Dranyi, O.A., Bachurin, S.O. Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons. Bull Exp Biol Med 136(5) 474-477 (2003).
7  Bachurin, S.O., Shevtsova, E.P., Kireeva, E.G., et al. Mitochondria as a target for neurotoxins and neuroprotective agents. Ann N Y Acad Sci 993 334-344 (2003).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
1 mg €30.00
5 mg €136.00
10 mg €240.00
100 mg €1,800.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.