10011301  p38 MAPK Monoclonal Antibody (Clone 9F12)

p38 MAPKα; p38 Mitogen-activated Protein Kinase

Clone designation: clone 9F12 · Host: mouse · Application(s): WB, ICC, and flow cytometry · p38 mitogen-activated protein kinase (MAPK) is a member of the serine-threonine MAPK family that triggers many cellular processes including cell cycle, development, and apoptosis.1,2 These kinases are activated by environmental stress signals such as osmotic shock, infection, and cytokines causing phosphorylation of p38 MAPK. This results in a phosphorylation cascade, activating transcription factors, and inducing gene expression.1,3 p38 MAPK is widely expressed in heart, brain, skeletal muscle, platelets, and immune cells. Due to this distribution, p38 MAPK plays a role in cardiovascular disease, arthritis, and cancer.2,4,5,3 It is mainly present in the cytosol, but can also be found in the nucleus after activation.2 Based on the amino acid sequence, the expected molecular weight of this protein is 41 kDa.
1  M. R. Junttila, S. P. Li and J. Westermarck. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. The FASEB Journal 22 1-12 (2008).
2  A. S. Dhillon, S. Hagan, S. Rath, et al. MAP kinase signalling pathways in cancer. Oncogene 26 3279-3290 (2007).
3  Y. Wang. Mitogen-activated protein kinases in heart development and diseases. Circulation 116 1413-1423 (2007).
4  G. Schett, J. Zwerina and G. Firestein. The p38 mitogen activated protein kinase (MAPK) pathway in rheumatoid arthritis. Annals of the Rheumatic Diseases 67 909-916 (2007).
5  A. Foster, B. Fitzsimmons, J. Rokach, et al. Evidence of in vivo ω-oxidation of peptide leukotrienes in the rat: Biliary excretion of 20-CO2H N-acetyl LTE4. Biochemical and Biophysical Research Communications 148 1237-1245 (1987).

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Pricing updated 2017-01-19.
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