10011190  SIRT1 (human recombinant)

Silent Information Regulator 2; Sirtuin 1; Sir 2

• See below for pricing and ordering
• See more Enzyme Activity; High Throughput Screening; Inhibitor Screening Assay; Western Blot; Enzymes; Histone Deacetylase; Proteins; Recombinant Proteins; Apoptosis; Cancer; Chromatin Research; Epigenetics; Histone Modification

For active pharmaceutical ingredients (APIs) related to SIRT1 (human recombinant), see Cayman Pharma

Related Articles

Frye, R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273 793-798 (2000).

Luo, J., Nikolaev, A.Y., Imai, S., et al. Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107 137-148 (2001).

Vaziri, H., Dessain, S.K., Eaton, E.N., et al. hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase. Cell 107 149-159 (2001).

Langley, E., Pearson, M., Faretta, M., et al. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J 21(10) 2383-2396 (2002).

Imai, S., Armstrong, C.M., Kaeberlein, M., et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 795-800 (2000).

Tanner, K.G., Landry, J., Sternglanz, R., et al. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci USA 97(26) 14178-14182 (2000).

Tanny, J.C., Moazed, D. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product. Proc Natl Acad Sci USA 98(2) 415-420 (2001).

Longo, V.D., Kennedy, B.K. Sirtuins in aging and age-related disease. Cell 126 257-268 (2006).


Download Product Insert 276 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Item total €0.00
Shopping cart total €0.00
Size Price Quantity
25 units €101.00
50 units €192.00
100 units €363.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.