10011190  SIRT1 (human recombinant)

NAD-dependent Deacetylase 1; SIR2L1; SIR2-like Protein 1; Sirtuin 1; Silent Information Regulator 2

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• See more Enzyme Activity; Enzymes; Proteins; Recombinant Proteins; Cancer; Chromatin Research; Epigenetics; Gene Regulation; Histone Modification; Metabolism

For active pharmaceutical ingredients (APIs) related to SIRT1 (human recombinant), see Cayman Pharma

Source: active recombinant N-terminal GST-tagged enzyme amino acids 193-747 purified from E. coli · Mr: 89.2 kDa · The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group.1,2,3 There are seven human sirtuins, which have been designated SIRT1-7.4 SIRT1, which is located in the nucleus, is the human sirtuin with the greatest homology to yeast Sir2 (Silent information regulator 2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis.5,6,7 These results have significant implications regarding an important role of SIRT1 in modulating the sensitivity of cells in the p53-dependent apoptotic response and the possible effect in cancer therapy. Since the growth suppressive function of p53 is strongly enhanced by DNA damaging reagents, it is expected that inhibitors of SIRT1 may be effective anti-cancer drugs.8
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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
25 units €107.00
50 units €203.00
100 units €384.00
Pricing updated 2013-05-21.
Prices are subject to change without notice.