10010744  SC-51322

(CAS 146032-79-3)



• See below for pricing and ordering
• See more Receptor Antagonist; Inflammation; Pain

For active pharmaceutical ingredients (APIs) related to SC-51322, see Cayman Pharma

The prostaglandin E2 (PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a murine writhing assay with an ED50 value of 0.9 mg/kg.1 It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089.1 SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE2 with an EC50 value of 7.75 µM.2
1  Hallinan, E.A., Hagen, T.J., Tsymbalov, S., et al. Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs. J Med Chem 39 609-613 (1996).
2  Foudi, N., Kotelevets, L., Louedec, L., et al. Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: Role of the EP4 receptor subtype. Br J Pharmacol 154 1631-1639 (2008).

Download Product Insert 115 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Item total €0.00
Shopping cart total €0.00
Size Price Quantity
1 mg €17.00
5 mg €76.00
10 mg €135.00
25 mg €294.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.