10010374  p38 MAPK (Phospho-Thr180/Tyr182) Cell-Based Phosphorylation/Translocation Assay Kit




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p38 MAPK is activated by phosphorylation at Thr180 and Tyr182 in response to both inflammatory cytokines and stress, making it an important enzyme in diseases like asthma and autoimmunity, as well as in the stress response of the nervous system. The subcellular location of p38 following stimulation is not well understood. Some evidence suggests that activated p38 translocates from the cytoplasm to the nucleus, whereas other reports indicate that phosphorylated p38 is present in the cytoplasm of stimulated cells. Cayman’s p38 Phosphorylation/Translocation Cell-Based Assay Kit provides a highly specific phospho-p38 MAPK (phospho-Thr180 and Tyr182) primary antibody together with a Dylight (product of Pierce Biotechnology, Inc.) conjugated secondary antibody in a ready-to-use format. Thrombin, which has been shown by scientists at Cayman Chemical to cause the translocation of phospho-p38 MAPK (phospho-Thr180 and Tyr182) into nuclei, is included as a positive control.

Download Kit Booklet 569 Kb PDF
Download Material Safety Data Sheet (MSDS) 72 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Warning This product is not for human or veterinary use.

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1 ea €390.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.