10010300  AG-18

RG-50810; Tyrphostin AG-18; Tyrphostin 23; TX 825; RG-50858 (CAS 118409-57-7)



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Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as protein tryrosine kinase blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation.1 AG-18 is an inhibitor of EGF receptor kinase with an IC50 value of 35 µM in the human epidermoid carcinoma cell line A431.1
1  Gazit, A., Yaish, P., Gilon, C., et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32(10) 2344-2352 (1989).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Warning This product is not for human or veterinary use.

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Size Price Quantity
5 mg €36.00
10 mg €69.00
25 mg €162.00
50 mg €288.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.