10010153  Aspirin™ Effect-Detection Kit



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Millions of Americans ingest daily 'mini-dose' (80 mg) aspirin™ as a means of selectively inhibiting platelet cyclooxygenase-1 (COX-1) and subsequent production of Thromboxane A2 (TXA2). Recent studies indicate that a subpopulation of these users do not achieve the desired level of inhibition of TXA2, as determined by its more stable metabolites. The Cayman Aspirin™ Effect-Detection Kit is a 510K, clinically approved diagnostic kit for the measurement of 11-dehydro TXB2. It is intended to help physicians assess the effectiveness of their patients' aspirin™ regime, and to help identify the high-risk group who are inadequately controlled on an 80 mg aspirin™ dose. Current methods for detecting aspirin™ resistance include a number of blood-based assays that measure in vitro platelet aggregation. However, these methods are not quantitative and can be affected by factors that are unrelated to aspirin™ sensitivity. In order to more quickly and accurately detect aspirin™ resistance in at-risk patients, we have developed a rapid, quantitative competitive immunoassay for 11-dehydro TXB2 using a monoclonal antibody. This new assay can be completed in three hours and utilizes urine as the sample matrix. The assay exhibits intra-assay %CV values of <11% with sensitivity sufficient to detect the lower levels of 11-dehydro TXB2 in patients that respond well to aspirin™. Thus, this sensitive, urine-based monoclonal ELISA for 11-dehydro TXB2 detection combines the speed of the blood-based assays with the sensitivity and quantitation of the ELISA.

Download Kit Booklet 570 Kb PDF
Download Material Safety Data Sheet (MSDS) 445 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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A 510(k) FDA-approved and CE-marked kit for human in vitro diagnostic use.

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1 ea €714.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.

Many of our kits require a source of UltraPure Water. If you do not have a source it is available for purchase from Cayman Chemical. Please check the Additional Items Required section of this kit booklet to verify if Ultra Pure Water is needed. Please note that the 480 well kits are supplied with a single 500 dtn vial of tracer and antiserum that must be used within the stated time following reconstitution. Please see the individual kit booklets for these details or contact techserv@caymanchem.com.