10009798  EX-527

(CAS 49843-98-3)



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• See more Inhibitors; Cell Biology; Epigenetics; Gene Regulation; Inflammation; Metabolism

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Mammalian sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM).1 It inhibits other SIRTs only at much higher concentrations and has no effect on other HDACs. EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.2
1  Nayagam, V.M., Wang, X., Tan, Y.C., et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11(8) 959-967 (2006).
2  Solomon, J.M., Pasupuleti, R., Xu, L., et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 26(1) 28-38 (2006).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
1 mg €20.00
5 mg €87.00
10 mg €154.00
25 mg €336.00
Pricing updated 2010-08-01.
Prices are subject to change without notice.