10009466  HDAC9 (human recombinant)

GenBank Accession No. NM 178423; Histone Deacetylase 9

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• See more Enzyme Activity; Inhibitor Screening Assay; Enzymes; Histone Deacetylase; Proteins; Recombinant Proteins; Cancer; Histone Modification; Inflammation

For active pharmaceutical ingredients (APIs) related to HDAC9 (human recombinant), see Cayman Pharma

Source: human recombinant protein consisting of amino acids 604-1,066 with a C-terminal His-tag expressed in Sf9 cells · Mr: 50.7 kDa · HDAC9 is a Class IIa HDAC which is homologous to the yeast HDAC1 and is larger in size than the other classes of HDACs.1,2 Class IIa HDACs contain a highly conserved C-terminal deacetylase catalytic domain (~420 amino acids) and N-terminal domain with no similarity to HDACs in other classes. Class II HDACs can shuttle between the nucleus and cytoplasm, suggesting possible extranuclear functions including regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play an important role in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation.1,2 Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.2
1  Lin, H., Chen, C., Lin, S., et al. Targeting histone deacetylase in cancer therapy. Med Res Rev 26(4) 397-413 (2006).
2  Huang, L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol 39.1, 611-616 (2006).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Warning This product is not for human or veterinary use.

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Pricing updated 2010-08-01.
Prices are subject to change without notice.