10008842  2,3-bis (4-Hydroxyphenyl) Propionitrile

DPN (CAS 1428-67-7)



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• See more Nuclear Receptors; Endocrinology

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2,3-bis(4-Hydroxyphenyl)propionitrile (DPN) is an estrogen receptor β (ERβ) selective agonist. DPN exhibits a 70-fold higher relative binding affinity for ERβ (18%) versus ERα (0.25%), about 80-fold higher transcriptional potency (EC50 = 0.85 nM versus 66 nM), and 170-fold higher relative potency (4.6% versus 0.025%) in transcription assays.1 Based on this selectivity, DPN is commonly used as a tool to evaluate the biological role of ERβ.
1  Meyers, M.J., Sun, J., Carlson, K.E., et al. Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogus. J Med Chem 44 4230-4251 (2001).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

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Size Price Quantity
5 mg €36.00
10 mg €69.00
50 mg €288.00
100 mg €504.00
Pricing updated 2010-09-09.
Prices are subject to change without notice.