10008661  JP 104



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• See more Eicosanoids; Fatty Acid Amides; Fatty Acids; Lipid Mediators; Neuroscience

For active pharmaceutical ingredients (APIs) related to JP 104, see Cayman Pharma

The enzyme, fatty acid amide hydrolase (FAAH), is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.1 JP104 is an irreversible FAAH inhibitor of the carbamate class with an IC50 of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate.2 The alkyl derivative on JP104 reacts with azide-modified reporter tags, such as azido-rhodamine or azido-biotin, for visualization of JP104 bound to FAAH in vivo.
1  Zhang, Y.H., Zhang, G.Y., Mollat, P., et al. Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein. J Biol Chem 268 18875-18881 (1993).
2  Alexander, J.P., Cravatt, B.F. Mechanism of carbmate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol 12 1179-1187 (2005).

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Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Warning This product is not for human or veterinary use.

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Size Price Quantity
5 mg €39.00
10 mg €74.00
50 mg €308.00
100 mg €538.00
Pricing updated 2010-09-09.
Prices are subject to change without notice.