10008012  SPD-304

(CAS 869998-49-2)



• See below for pricing and ordering
• See more Cytokines; Receptor Antagonist; Apoptosis; Inflammation

For active pharmaceutical ingredients (APIs) related to SPD-304, see Cayman Pharma

Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.1,2,3 TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. 4,5 SPD-304 is an inhibitor of TNFα that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.6 It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.6
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Download Product Insert 115 Kb PDF
Download Material Safety Data Sheet (MSDS) 23 Kb PDF

Pricing Information

Prices listed here are the Manufacturer's Suggested European Retail Price. The actual prices quoted by each individual distributor may vary. Please visit the Global Buyer's Guide on the Cayman Chemical (world) website to locate a distributor in your region.

This product is also available to buy in bulk quantities. Please contact us for a quote or to purchase.

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Warning This product is not for human or veterinary use.

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Size Price Quantity
500 µg €28.00
1 mg €53.00
5 mg €221.00
10 mg €387.00
Pricing updated 2013-05-21.
Prices are subject to change without notice.