10008012  SPD-304

(CAS 869998-49-2)

Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.1,2,3 TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. 4,5 SPD-304 is an inhibitor of tumor necrosis factor α (TNFα). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.6 It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.6
1  B. Beutler, D. Greenwald, J. D. Hulmes, et al. Identity of tumor necrosis factor and the macrophage-secreted factor cachectin. Nature 316 552-554 (1985).
2  missing reference text
3  missing reference text
4  N. A. Thornberry and Y. Lazebnik. Caspases: Enemies within. Science 281 1312-1316 (1998).
5  missing reference text
6  M. M. He, A. S. Smith, J. D. Oslob, et al. Small-molecule inhibition of TNF-α. Science 310 1022-1025 (2005).

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Size Price Quantity
500 µg €29.00
1 mg €55.00
5 mg €230.00
10 mg €403.00
Pricing updated 2017-01-19.
Prices are subject to change without notice.