10008012  SPD-304

(CAS 869998-49-2)




Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.1,2,3 TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. 4,5 SPD-304 is an inhibitor of tumor necrosis factor α (TNFα). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.6 It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.6
1  Beutler, B., Greenwald, D., Hulmes, J.D., et al. Identity of tumor necrosis factor and the macrophage-secreted factor cachectin. Nature 316 552-554 (1985).
2  missing reference text
3  missing reference text
4  Thornberry, N.A., and Lazebnik, Y. Caspases: Enemies within. Science 281 1312-1316 (1998).
5  missing reference text
6  He, M.M., Smith, A.S., Oslob, J.D., et al. Small-molecule inhibition of TNF-α. Science 310 1022-1025 (2005).

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Size Price Quantity
500 µg €28.00
1 mg €53.00
5 mg €221.00
10 mg €387.00
Pricing updated 2014-12-22.
Prices are subject to change without notice.