Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.1,2,3 TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. 4,5 SPD-
1 Beutler, B., Greenwald, D., Hulmes, J.D., et al. Identity of tumor necrosis factor and the macrophage-
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4 Thornberry, N.A., and Lazebnik, Y. Caspases: Enemies within. Science 281 1312-1316 (1998).
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6 He, M.M., Smith, A.S., Oslob, J.D., et al. Small-
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