Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.1,2,3 TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. 4,5 SPD-
1 B. Beutler, D. Greenwald, J. D. Hulmes, et al. Identity of tumor necrosis factor and the macrophage-
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4 N. A. Thornberry and Y. Lazebnik. Caspases: Enemies within. Science 281 1312-1316 (1998).
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6 M. M. He, A. S. Smith, J. D. Oslob, et al. Small-
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