10007964  E-64c

NSC 694279; Loxistatin Acid; EP 475 (CAS 76684-89-4)




Cysteine proteases are a class of enzymes containing an active-site cysteine residue that are important in protein degradation pathways. E-64c is a synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor isolated from Aspergillus japonicus.1 E-64c inhibits the cysteine proteases cathepsin B and cathepsin L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.2 The ethyl ester of E-64c, E-64d, is cell permeable and hydrolyzed in cell culture to E-64c. E-64d arrests the growth of A431 cells in metaphase at concentrations between 20-200 µg/ml.2
1  Drahl, C., Cravatt, B.F., and Sorensen, E.J. Protein-reactive natural products. Angew Chem Int Ed 44 5788-5809 (2005).
2  Shoji, Y., Senshu, M., Iwashita, S., et al. Thiol protease-specific inhibitor E-64 arrests human epidermoid carcinoma A431 cells at mitotic metaphase. Proc Natl Acad Sci USA 85 146-150 (1988).

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1 mg €59.00
5 mg €266.00
10 mg €471.00
25 mg €1,030.00
Pricing updated 2014-09-17.
Prices are subject to change without notice.